Introduction: Self-Management education is the key component of diabetes care. Furthermore, high levels of patient non-compliance or non-adherence to the treatment regimen suggest that patient education for selfManagement is faced with some shortcomings. This study aimed to identify Barriers to effective diabetes selfManagement education.Methods: This is a traditional review of published studies during 1990-2010 on Barriers to diabetes selfManagement and control. Electronic search through Iranian and international databases was done.Results: Barriers to effective diabetes self-Management education were put in two main categories including patient-related Barriers and caregiver-related Barriers. The most common patient-related Barriers are demographic Barriers (such as age, sex, education, and health literacy), financial problems, lack of attention to the disease, psychological problems, and insufficient knowledge. Patient-caregiver relationship, inadequate knowledge, and high workload were caregiver-related Barriers.Conclusion: The results of this review introduced a variety of factors that can affect the effectiveness of diabetes self-Management education. Patients and caregivers are facing serious challenges due to these Barriers. Understanding and attemping to overcome these Barriers may help us to empower patients to achieve self-Management.